VKORC1 Gene Analysis of Some Iranian Sensitive Patients to Warfarin
نویسندگان
چکیده
منابع مشابه
Effect of VKORC1 Gene Polymorphism on Warfarin Response in Razavi Khorasan Province Cardiovascular Patients
Background and Aims: Warfarin is an anticoagulant agent used for many years in treating various clinical conditions such as thromboembolisms in cardiovascular disease. Some patients require different doses of warfarin to reach the therapeutic international normalized ratio ratio. These patients have specific demographic characteristics. Genetic polymorphisms in specific genes have been reported...
متن کاملIdentification of CYP2C9 and VKORC1 polymorphisms in Iranian patients who are under warfarin therapy
BACKGROUND Although catalytic properties of different genetic polymorphisms of VKORC1 and CYP2C9 products have been identified, there is limited study available regarding warfarin dose requirement in Iranian patient population. This study investigates the impact of these polymorphisms on 115 patients, referred to Payvand Clinical and Specialty Laboratory for determining the appropriate dose of ...
متن کاملAssociation of Warfarin Therapy with APOE and VKORC1 Genes Polymorphism in Iranian Population
Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...
متن کاملFrequency of two VKORC1 gene variants and its correlation with warfarin maintenance dose
Warfarin is a commonly-prescribed anticoagulant used to treat and prevent thromboembolic events. The requirement for varying doses of warfarin depends on genetic and environmental components. In this study, the frequency of two single-nucleotide polymorphic variants of the vitamin K epoxide reductase complex subunit 1 (VKORC1) gene (1173 C>T (rs9934438) and 3730 G>A (rs7294)) and its correlatio...
متن کاملAssociation of Warfarin Therapy with APOE and VKORC1 Genes Polymorphism in Iranian Population
Warfarin is a vitamin K antagonist that genetic and non-genetic factors affected on its doserequirement in the patients with cardio vascular disease. The aim of this study was whetherthe APOE and VKORC1 polymorphisms influence on warfarin dose requirements in the partof Iranian patients. Blood samples were collected from 86 warfarin-treated patients. Afterextraction of genomic DNA, the VKORC1 (...
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ژورنال
عنوان ژورنال: Pakistan Journal of Biological Sciences
سال: 2010
ISSN: 1028-8880
DOI: 10.3923/pjbs.2010.906.910